Disease progression in young patients with COPD: rethinking the Fletcher and Peto model

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Disease progression in young patients with COPD: rethinking the Fletcher and Peto model.

Chronic obstructive pulmonary disease (COPD), although frequent in older individuals, can also occur at younger age; this latter population has not been well described. We reviewed the functional progression of 1708 patients with COPD attending pulmonary clinics. Those with three or more annual spirometries were divided into those who, at enrolment, were ≤ 55 (n = 103) or ≥ 65 (n = 463) years o...

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Chronic obstructive pulmonary disease (COPD) is a leading cause of death and disability internationally. Alveolar hypoxia and consequent hypoxemia increase in prevalence as disease severity increases. Ventilation/perfusion mismatch resulting from progressive airflow limitation and emphysema is the key driver of this hypoxia, which may be exacerbated by sleep and exercise. Uncorrected chronic hy...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2014

ISSN: 0903-1936,1399-3003

DOI: 10.1183/09031936.00208613